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FAIR4Rare focuses on three selected diseases that differ significantly in their frequency, type of care and existing registries: 

Osteogenesis imperfecta (OI) and related fragility disorders are rare genetic diseases characterised by bone fragility and other symptoms. The prevalence of OI is approximately 1:10,000 and there is currently no national registry for this disease. 

Monogenic forms of obesity are ultra-rare diseases that are caused by specific genetic mutations. The prevalence is less than 1:1,000,000 and there is no national or European register for these diseases. 

Cystic fibrosis (CF) is a disease caused by mutations in the CFTR gene. The prevalence is about 1:3,000 and there is a comprehensive national registry for CF.